Frontotemporal Dementia

A Phase 1 Trial

Frontotemporal dementia is a group of conditions caused by the death of nerve cells and pathways in the frontal and temporal lobes of the brain. Frontotemporal dementia has three variants, depending on which parts of the brain are affected and the symptoms that appear. Frontotemporal dementia is caused when nerve cells in the frontal and/or temporal lobes of the brain die and the pathways that connect them change. Researchers have identified specific genes are related to a higher risk of developing frontotemporal dementia. As FTD progressively worsens, a person may engage in dangerous behaviors or be unable to care for himself or herself. As each person with FTD is different, the speed of decline and the manifestation of symptoms will vary.

A Subgroup Of Patients With Frontotemporal Dementia

About 10-15 per cent of young-onset dementia could be due to frontotemporal dementia which causes progressive degeneration of the frontal and temporal lobes of the brain. As the disease progresses, less and less language is used, until the patient becomes virtually mute. Various underlying neuropathological entities lead to the frontotemporal dementia clinical phenotype, all of which are characterised by the selective degeneration of the frontal and temporal cortices. Patients with semantic dementia typically have temporal lobe atrophy, often involving the anterior temporal lobes bilaterally. The clinical pattern reflects the topographic pattern of atrophy, often visible radiographically, with asymmetrical frontotemporal atrophy. Gross examination of the brain showed mild atrophy of the frontal, parietal, and occipital lobes, with moderate atrophy of the temporal lobe.

Signs And Symptoms Of The Disease

People who develop dementia at a younger age may have a strong family history of dementia. The symptoms of dementia can vary, depending on which parts of the brain are affected. In the early stages of Lewy body dementia, symptoms can be mild, and people can function fairly normally. People with dementia will always see their symptoms worsen over time, but not every person with the same type of dementia will decline at the same rate or experience the same symptoms at the same stage. Treatments may help to maintain mental function longer, manage behavioral symptoms, and slow down the symptoms of disease. The precise symptoms vary with the type of dementia, stage of disease, and from person to person.

Home Health Care

Loved ones who are caring for a person with dementia at home can also provide valuable support. Respite will work most effectively if you can find a service that both the person with dementia and carer find attractive and valuable. The home carers try their best to develop friendly relations whilst providing support and care. Dementia patients need a safe, familiar environment, either at home or in long-term residential care. A regular home carer can be employed to come into the home to provide help, support and a friendly face. An in-home carer would not only help with providing support but would also be emotionally present for the patient so that s/he does not feel irrelevant or left out at any time.

The Anatomy Of Mouse

Frontotemporal dementia is a common cause of dementia in people under the age of 65. Unfinished nests were scored 1, 2, or 3, depending on the height of the walls. The option is a good pick for people who need help while bathing, dressing, or feeding. The symptoms of dementia are similar, though the cause is what makes the final diagnosis as to the type of dementia. Personality and behavioral changes, including the Kluever-Bucy syndrome, were the first symptoms in 12 individuals. Frontotemporal dementia is a common type of dementia, particularly in patients younger than 65 years.

Daily Work Or Family Routines

People over 40 should have their eyes checked every two years and people over 60 should have their eyes checked every year. Once you select your test and enter your result, the analyzer will tell you if it is low, optimal, or high and what that might mean. When caring for an individual with FTD, one must remember to always try to be sensitive, patient, and understanding. Cognitive or mental decline starts years earlier, but often does not become evident until senior years when daily work or family routines become less regimented. You may blink your eyes rapidly, or your lips and jaw may tremble as you struggle to get the words out. The test is intended to be administered and graded by a medical professional, who will then decide if more tests are necessary.

Frontotemporal Dementia And Motor Neurone Disease

There was no correlation between number of repeats and age at onset or disease duration. The average number of pathogenic repeats on the disease haplotype was 8, with a spread of expanded alleles up to 26. The mean age of onset in sporadic cases varies among series but overall is 55-65 years. The mean age at onset was 57.9 years, and the mean disease duration was 3.6 years. The disease is more common among the elderly, and its prevalence increases with age to a rate of ? 20% for patients over the age of 85 years.


Comments

Popular Posts